Strategic behaviour in Schelling dynamics: theory and experimental evidence

In this paper we experimentally test Schelling’s (1971) segregation model and obtain the striking result of full segregation in most of the cases. In addition, we extend Schelling’s model theoretically by adding strategic behaviour and moving costs. We obtain a unique subgame perfect equilibrium in which rational agents facing moving costs may find it optimal not to move (anticipating other participants’ movements). This equilibrium is far from full segregation. We run experiments for this extended Schelling model, and find that the percentage of full segregated societies is notably reduced when the cost of moving is high, but it is not affected when it is low, relative to the baseline with costless moving. We also find that the degree of segregation depends on the distribution of strategic subjects relative of a baseline model where moving is costless

Power scaling rules for charmonia production and HQEFT

We discuss the power scaling rules along the lines of a complete Heavy Quark Effective Field Theory (HQEFT) for the description of heavy quarkonium production through a color-octet mechanism. To this end, we firstly derive a tree-level heavy quark effective Lagrangian keeping both particle-antiparticle mixed sectors allowing for heavy quark-antiquark pair annihilation and creation, but describing only low-energy modes around the heavy quark mass. Then we show the consistency of using HQEFT fields in constructing four-fermion local operators a la NRQCD, to be identified with standard color-octet matrix elements. We analyze some numerical values extracted from charmonia production by different authors and their hierarchy in the light of HQEFT.Comment: LaTeX, 19 pages, 3 EPS figure

Selective Boosting of Transcriptional and Behavioral Responses to Drugs of Abuse by Histone Deacetylase Inhibition

Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Earlier studies have shown that a reduction in histone deacetylase (HDAC) activity results in the enhancement of some psychostimulant-induced behaviors. In this study, we extend those seminal findings by showing that the administration of the HDAC inhibitor sodium butyrate enhances morphine-induced locomotor sensitization and conditioned place preference. In contrast, this compound has no effects on the development of morphine tolerance and dependence. Similar effects were observed for cocaine and ethanol-induced behaviors. These behavioral changes were accompanied by a selective boosting of a component of the transcriptional program activated by chronic morphine administration that included circadian clock genes and other genes relevant to addictive behavior. Our results support a specific function for histone acetylation and the epigenetic modulation of transcription at a reduced number of biologically relevant loci on non-homeostatic, long-lasting, drug-induced behavioral plasticity

Prime numbers, quantum field theory and the Goldbach conjecture

Motivated by the Goldbach conjecture in Number Theory and the abelian bosonization mechanism on a cylindrical two-dimensional spacetime we study the reconstruction of a real scalar field as a product of two real fermion (so-called \textit{prime}) fields whose Fourier expansion exclusively contains prime modes. We undertake the canonical quantization of such prime fields and construct the corresponding Fock space by introducing creation operators $b_{p}^{\dag}$ --labeled by prime numbers $p$-- acting on the vacuum. The analysis of our model, based on the standard rules of quantum field theory and the assumption of the Riemann hypothesis, allow us to prove that the theory is not renormalizable. We also comment on the potential consequences of this result concerning the validity or breakdown of the Goldbach conjecture for large integer numbers.Comment: 20 pages in A4 format, 2 figure

Semiclassical zero-temperature corrections to Schwarzschild spacetime and holography

Motivated by the quest for black holes in AdS braneworlds, and in particular by the holographic conjecture relating 5D classical bulk solutions with 4D quantum corrected ones, we numerically solve the semiclassical Einstein equations (backreaction equations) with matter fields in the (zero temperature) Boulware vacuum state. In the absence of an exact analytical expression for in four dimensions we work within the s-wave approximation. Our results show that the quantum corrected solution is very similar to Schwarzschild till very close to the horizon, but then a bouncing surface for the radial function appears which prevents the formation of an event horizon. We also analyze the behavior of the geometry beyond the bounce, where a curvature singularity arises. In the dual theory, this indicates that the corresponding 5D static classical braneworld solution is not a black hole but rather a naked singularity.Comment: 26 pages, 4 figures; revised version (title changed, conclusions shortened), published as Phys. Rev. D73, 104023 (2006

Virus satellites drive viral evolution and ecology

Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However, the evolutionary and ecological implications of satellites on helper viruses remain unclear. Here, using staphylococcal pathogenicity islands (SaPIs) as a model of virus satellites, we experimentally show that helper viruses rapidly evolve resistance to their virus satellites, preventing SaPI proliferation, and SaPIs in turn can readily evolve to overcome phage resistance. Genomic analyses of both these experimentally evolved strains as well as naturally occurring bacteriophages suggest that the SaPIs drive the coexistence of multiple alleles of the phage-coded SaPI inducing genes, as well as sometimes selecting for the absence of the SaPI depressing genes. We report similar (accidental) evolution of resistance to SaPIs in laboratory phages used for Staphylococcus aureus typing and also obtain the same qualitative results in both experimental evolution and phylogenetic studies of Enterococcus faecalis phages and their satellites viruses. In summary, our results suggest that helper and satellite viruses undergo rapid coevolution, which is likely to play a key role in the evolution and ecology of the viruses as well as their prokaryotic hosts